Let us start with the boundary
Psoriasis, atopic dermatitis, eczema and rosacea are diseases. Their treatment is led by a doctor, most often a dermatologist, and no cosmetology treatment replaces that.
With these diagnoses, the treatment can only be supportive care, aimed at skin comfort and its barrier, carried out in agreement with the treating doctor and only on skin without a flare-up.
On this page
What xanthohumol is and the stabilisation technology
Xanthohumol is a compound of plant origin, described as a strong antioxidant with anti-inflammatory action. The problem with its use in cosmetics was its limited bioavailability, meaning the difficulty of delivering it to the skin in an active form.
The manufacturer solved this by enclosing xanthohumol in a cyclodextrin molecule, which is said to allow it to be delivered to deeper layers of the skin. In the preparations, xanthohumol appears together with other active ingredients, including vitamin C, lactoferrin, coenzyme Q10, niacinamide and tranexamic acid.
Information about the composition and technology comes from the manufacturer's materials. We do not carry over claims of many times greater efficacy than other antioxidants, because such a comparison requires citing the study, its conditions and the effect size.
Described mechanisms of action
Below are the mechanisms attributed to xanthohumol in the product materials. This is a description of the ingredient's direction of action, not a promise of a treatment effect for a specific person.
Antioxidant action
Neutralising free radicals that form in the skin under the influence of ultraviolet radiation, pollution and stress, and that can damage proteins, lipids and cell DNA.
Anti inflammatory effect
Influence on signalling pathways that control the production of pro-inflammatory cytokines, including the NF-kappa B pathway. This is said to limit redness, swelling and irritation.
Influence on metalloproteinases
Inhibiting the activity of MMP-1 and MMP-8, enzymes that break down collagen. Excessive activity of these enzymes accelerates the loss of skin firmness.
Action on skin tone
Influence on melanogenesis pathways, meaning melanin formation, which is said to support an even skin tone and reduce the visibility of pigmentation.
Antimicrobial action
Reducing the number of microorganisms on the surface of the skin, which in the product materials is linked to supporting skin with inflammatory lesions.
Main application: after remodelling treatments
Some treatments work precisely by triggering a controlled inflammatory response, to stimulate the skin to produce collagen and rebuild itself. This is how microneedling mesotherapy, RF microneedling and laser therapy work.
This is where the xanthohumol preparation has its clearest role: not to remove that inflammatory response, because it is the aim of the treatment, but to stabilise it and support the rebuilding of the epidermal barrier. For the same reason, in the price list PRO XN appears in combinations with microneedling and with microneedling mesotherapy, and not only on its own.
The order matters here and is set by the cosmetologist. Not every preparation is suitable for use directly after a treatment that breaches the skin barrier.
Three treatment grades
In the price list, the treatment comes in three grades. The difference is whether the preparation works alone or together with a method that breaches the epidermis.
First grade
The care protocol alone, without breaching the epidermis. The mildest variant, considered as support for the skin barrier and an introduction to the therapy.
Second grade, with microneedling
A protocol combined with microneedling, which makes it easier to introduce the ingredients and itself stimulates the skin to rebuild.
Third grade, with microneedling mesotherapy
A protocol combined with microneedling mesotherapy. The deepest work and the clearest skin reaction after the treatment.
The higher the level, the deeper we work and the clearer the skin reaction after the treatment. The level is selected by the cosmetologist after assessing the skin, not by the patient when booking.
Skin with a chronic condition: what we can and cannot do
People with psoriasis, atopic dermatitis, eczema or rosacea often look for care that will not aggravate their skin condition. This is reasonable, and cosmetology has its place here. The boundary, however, is clear.
Belongs to the practice
Supportive care, focused on skin comfort and barrier repair.
Selecting products that do not aggravate the skin condition.
Support for regeneration after treatments performed at the clinic.
Belongs to the doctor
Diagnosing the skin disease and treating it.
Pharmacotherapy and decisions on changing or discontinuing it.
Managing flare-ups. We do not perform the treatment during a flare-up.
If you come to us with a diagnosed skin disease, tell us about it and about any medicines you are taking at the consultation. Some products and some treatments are then excluded, and we set the plan so that it does not interfere with your treatment.
What this treatment will not do
It will not cure a skin disease and will not replace treatment provided by a doctor.
It will not replace sunscreen. Antioxidants limit the effects of oxidative stress, but they do not block ultraviolet radiation.
It is not a volumising or tightening treatment. It works on the condition and barrier of the skin, not on supporting it.
It will not work as a one-off, separate from home care, because rebuilding the skin barrier requires continuity.
Assessment and after the treatment
The treatment is preceded by a skin assessment and interview. We do not give the number of sessions or the degree of improvement before qualification, as these depend on the condition of the skin, the chosen treatment level and home care.
Temporary swelling, tenderness and redness may occur after the treatment. With levels that include microneedling, the reaction is more pronounced, and the recommendations appropriate for treatments that breach the continuity of the epidermis apply, including photoprotection. Recommendations for the following days are given by the cosmetologist after the treatment.
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Responsible for the content
NL Clinic, Katowice
How the content is created
Last updated
24 August 2026
This material is for information purposes only and does not replace a consultation, examination or treatment provided by a doctor.
The questions we are asked most often
Does PRO XN treat psoriasis, atopic dermatitis or rosacea?
No. Psoriasis, atopic dermatitis, eczema and rosacea are diseases, and their treatment is led by a doctor, most often a dermatologist. The cosmetology treatment can be supportive care, focused on comfort and the skin barrier, and it does not replace treatment or remove the need for check-ups with a doctor.
What is xanthohumol?
It is a plant derived compound with antioxidant and anti-inflammatory properties. Its problem in cosmetics was limited bioavailability, so in PRO XN products it is enclosed in a cyclodextrin molecule, which is intended to improve its delivery to the skin.
What is this treatment best suited to?
To supporting the skin after treatments that deliberately trigger a controlled inflammatory response, that is after microneedling mesotherapy, microneedling RF and laser therapy. The product is aimed at stabilising this reaction and rebuilding the skin barrier, so it is often an element of a plan rather than a treatment in its own right.
What is the difference between the three treatment levels?
The first level is the care protocol alone. The second combines it with microneedling, and the third with microneedling mesotherapy. The higher the level, the deeper we work and the greater the skin reaction. The level is selected by the cosmetologist after assessing the skin.
How long does the treatment take and is it painful?
The first treatment takes about 60 minutes. For comfort, we apply anaesthetic cream. Temporary swelling, tenderness and redness may occur after the treatment, and with levels that include needling, the skin reaction is more pronounced.
Will the product replace sunscreen?
No. Antioxidant action is not the same as sun protection. Antioxidants limit the effects of oxidative stress, but they do not block ultraviolet radiation, so daily photoprotection remains essential.
The content is informational in nature. It does not replace a consultation, examination or treatment carried out by a doctor.