Legal note
The content is for information. It does not replace a consultation, an examination or an individual medical assessment.
The material comes solely from the person to whom it will be administered and is not stored for later. The mechanisms described relate to how fibrin acts in the tissue and are not a promise of an effect in a specific person.
On this page
What fibrin is
Fibrin is a protein that the body produces with every cut. It is formed from fibrinogen present in plasma and creates a mesh that stops bleeding and provides the first scaffold for a healing wound. It is a natural part of clotting, not a foreign substance.
In aesthetic medicine, the same mechanism is used deliberately. The preparation is made from the patient's blood taken just before the treatment and is injected into the chosen area to create a structure there that supports tissue rebuilding.
It belongs to the autologous preparations, meaning those that come from the same person to whom they will be given. We describe the context of the whole group on the blood-derived preparations page.
How the fibre mesh is formed
The starting point is the same as with plasma: drawing blood and spinning it in a centrifuge. The difference lies in which fraction is drawn into the syringe and under what conditions the material is prepared for injection.
Under the influence of clotting enzymes, fibrinogen turns into a mesh of fibrillar fibres. This mesh has a denser consistency than plasma and spreads more slowly through the tissue. It is precisely this feature that determines when fibrin tends to be chosen.
The preparation is made and administered at the same visit. The material cannot be prepared in advance, because the conversion of fibrinogen begins after it is drawn and does not pause while waiting for the next appointment.
How fibrin acts in the tissue
Once injected into the tissue, the mesh acts as a scaffold: it gives the cells involved in repair a structure to move along and to deposit new fibres in. An effect on stimulating fibroblasts to produce collagen has also been described, which is the same direction of action as with the other biostimulating preparations.
This is what determines the range of uses. Fibrin is chosen mainly where the tissue needs to rebuild something: for scars, for defects, for supporting healing. For simply improving hydration and skin tone, plasma is usually enough.
Fibrin and platelet-rich plasma
Both preparations come from the same draw and the same blood. The difference only becomes visible in what stays in the syringe.
Platelet-rich plasma
A liquid preparation with a high content of platelets and growth factors. It spreads through the tissue and works mainly by stimulating cells. Chosen when working on skin quality.
Fibrin
A mesh of fibres with a denser consistency. It stays longer at the injection site and acts as a supporting structure for tissue rebuilding. Chosen where the tissue needs to rebuild something.
This is not a choice between a better or worse preparation, but between two different tasks. They are sometimes used together in one plan. You will find a description of plasma on the platelet-rich plasma page.
When it tends to be chosen
Scars
Post-surgical, post-acne and post-injury. Fibrin supports tissue rebuilding within the scar, usually as part of combination therapy.
Tissue defects
Places where the tissue needs rebuilding, not just a stimulus to work.
Healing support
After treatments and injuries, when the goal is the healing process, not a change in the skin's appearance.
Skin density and elasticity
Working on tissue quality in areas where plasma can be insufficient.
For scars, fibrin is usually part of combination therapy, not the whole therapy. Whether a scar first needs remodelling using a laser method or microneedling is decided by an assessment of its type, age and depth.
What fibrin will not do
It will not fill a furrow the way a hyaluronic acid filler does. Fibrin is absorbed and does not build permanent volume.
It will not change the facial contour or replace a lift.
It will not remove a scar. Scar therapy reduces its visibility, and the extent of the change depends on the scar's type, age and depth.
It will not work faster than the tissue itself. Rebuilding is measured in weeks, regardless of how many treatments were carried out.
Course of a fibrin treatment
The first treatment takes from 45 minutes, including the blood draw and preparing the material. We use anaesthetic cream for comfort, although it is not required.
Effects of a fibrin treatment and after how long
The change builds up over weeks, because it is based on tissue rebuilding, not on the presence of the material. Fibrin is absorbed, and what remains is the result of the work carried out by the tissue around the network of fibres.
The extent and duration of the effect depend on the type of change, the condition of the tissue and the material obtained from that particular blood draw. For scars, the result is assessed after the whole course of therapy, not after a single treatment.
We publish photos of results only with patients’ consent and under comparable conditions: the same framing, light, facial expression and time interval. The result is always individual.
Reactions after the treatment
Expected reactions
Redness, swelling and tenderness at the injection points, sometimes minor bruising, also at the blood draw site. These are temporary.
No pressing on the area
For the first 24 hours, do not massage or press on the treated area, unless the doctor has advised otherwise.
No high temperatures
Sauna, steam baths, swimming pool and sunbeds only after two weeks.
Sun protection
Sun protection on the treated area for a few days. When working on scars, sun protection matters for the whole duration of the therapy.
The treatment does not require recovery time. Increasing pain, warmth and redness in the area after a few days require contact with the clinic.
Contraindications for a fibrin treatment
This list is shared across the whole group of blood-derived preparations, because it covers both the blood draw and the injection of the material into the tissue.
With fibrin, clotting disorders and medications affecting blood clotting matter in particular, because the whole material relies on that process. Report them before your appointment and do not stop taking anything on your own.
The questions we are asked most often
What is fibrin in aesthetic medicine?
It is an autologous material, prepared from the patient's blood taken just before the treatment. It forms from fibrinogen, a protein involved in clotting, which turns into a network of fibres under the action of enzymes. This network stays at the injection site and acts as a scaffold for tissue rebuilding.
How does fibrin differ from platelet-rich plasma?
Both materials are prepared from the same blood draw. Plasma is liquid and works mainly through growth factors that stimulate cells. Fibrin has a denser, net-like structure, stays at the injection site for longer and supports tissue rebuilding as a scaffold. These are two different tasks, not a better material and a worse one.
What is fibrin used for?
Most often where we want to support healing and tissue rebuilding: for scars, including post-surgical and post-acne scars, for skin defects, and when working on skin density and elasticity. For improving hydration and skin tone alone, plasma is usually enough.
Does fibrin fill wrinkles?
Not in the way a hyaluronic acid filler does. Fibrin does not build permanent volume and is absorbed. For a furrow resulting from volume loss, a filler is the right method, and for a wrinkle caused by muscle movement, a different method again.
Is a fibrin treatment safe for people with allergies?
The material comes solely from the person it will be given to, so there is no risk of a reaction to a foreign material. There is, however, still a risk related to the injection itself, to the blood draw and to infection, and contraindications include, among others, clotting disorders and blood diseases.
How much does a fibrin treatment cost?
The cost depends on the area and the number of treatments, so we keep a single up-to-date aesthetic medicine price list instead of scattered amounts on individual pages. You will find out the price at the consultation, once a plan has been agreed.
Who performs the fibrin treatment?
An aesthetic medicine doctor, after a consultation and qualification. The treatment involves drawing blood, preparing the product under sterile conditions, and administering it into the tissue. Each of these stages is a medical procedure.
The content is for information. It does not replace a consultation, an examination or an individual medical assessment.