Status of the preparation
The manufacturer, the Italian company CMed Aesthetics, declares BioRePeel Cl3 as a medical device. This is information about the status of the preparation, not about the efficacy of the treatment.
You have the right to ask the practice for the product documentation before the treatment. This page describes a service performed at the clinic, not a promotion of the preparation itself.
On this page
Two phases and what they do
The name "two-phase" is not a marketing term here. The preparation genuinely consists of two layers of different character, which are combined immediately before the treatment.
Hydrophilic phase
Six acids: trichloroacetic, lactobionic, salicylic, tartaric, citric and gamma-aminobutyric (GABA). In addition, four amino acids (glycine, proline, hydroxyproline, arginine) and vitamins C and B2. This is the phase that works on the skin.
Lipophilic phase
Contains squalane and isopropyl myristate. Its role is to protect the hydrophilic phase from oxidation and to stabilise the formulation of the preparation.
The point of this separation is practical: the acids and vitamin C oxidise on contact with air, and the lipophilic phase prevents this until the moment of use.
How it works on the skin
The action described for the preparation has two pathways that run in parallel.
Exfoliating pathway
A keratolytic action, affecting the connections between corneocytes, speeds up the removal of the outer cells of the stratum corneum.
Biostimulating pathway
On contact with the skin, proteins in the outer layer denature and a biochemical cascade is triggered, described as leading to the production of growth factors. In this process, the amino acids and vitamins are said to act as substrates and cofactors for the repair processes.
The difference from PRX-T33, which is also based on TCA and also limits flaking, lies in the accompanying composition: there, kojic acid and hydrogen peroxide, here, a complex of amino acids and vitamins. Which preparation is more suitable depends on the aim of the treatment and the condition of the skin.
Variants for the face and body
FND variant, 35 percent TCA
Face, neck and décolletage.
Areas with thinner skin and a denser network of vessels, where excessive flaking more easily leads to adverse reactions. Treatments are usually carried out at intervals of 7 to 10 days.
BODY variant, 50 percent TCA
Body: hands, elbows, knees, back, arms, thighs and buttocks.
A higher concentration and larger volume, intended for the thicker skin of the body. The intervals between treatments are longer, usually 10 to 15 days.
The cosmetologist selects the variant for the treatment area. This is not the same preparation in two packages, but two different formulas.
Indications
With pigmentation, it is worth remembering that the peel works on pigment already deposited in the epidermis. If the skin is still producing it, tranexamic acid, which acts on the pathway of melanin formation, is often more suitable.
Combining with microneedling
Microneedling increases the absorption of active ingredients, so the price list offers the preparation both on its own and combined with microneedling and with microneedle mesotherapy.
Combining the two means more intensive work and a more visible skin reaction, as well as a break in the epidermis that the peel alone does not cause. Whether such a combination makes sense is decided at the consultation, not when booking.
What we will not write about this treatment
The commercial materials for this preparation use claims we do not repeat, and it is worth knowing why.
“Does not cause flaking or irritation”, the formula limits visible flaking but does not remove the skin reaction. For a preparation based on TCA, a promise of no irritation would be dishonest.
“Safe” without qualification, no treatment is safe for everyone. That is why we state the contraindications instead.
“Immediate effect”, a promise of a result within a set time that cannot be guaranteed for every skin.
“No scarring after the treatment” and “no frosting effect”, these statements describe the typical course, not a guarantee. The skin reaction depends on the area, the concentration of the variant and individual sensitivity.
Contraindications and assessment
The preparation is based on trichloroacetic acid, so the contraindications proper to acid peels apply.
You will find the full list for all acids, together with photosensitising medicines and the break after oral therapy with vitamin A derivatives, on the acid peels page. We do not state the number of sessions before qualification.
Editorial responsibility
Responsible for the content
NL Clinic, Katowice
How the content is created
Last updated
13 August 2026
This material is informational in nature and does not replace a consultation or qualification.
The questions we are asked most often
What does it mean that BioRePeel is a two-phase peel?
The preparation consists of two phases. The hydrophilic phase contains acids and a complex of vitamins and amino acids, and it is this phase that works on the skin. The lipophilic phase, with squalane and isopropyl myristate, protects the first phase from oxidation and stabilises the formulation. Both phases are mixed just before the treatment.
How does BioRePeel differ from a classic TCA peel?
A classic TCA peel works through controlled damage and exfoliation of the epidermis, with visible frosting of the skin and a recovery period of several days. The BioRePeel formula is designed to limit this visible reaction while keeping the effect on the skin, thanks to the presence of a biostimulating complex alongside the acids. This does not mean, however, that the skin does not react.
Are there different variants of the preparation?
Yes, two, and they differ in the concentration of trichloroacetic acid. The FND variant for the face, neck and decolletage contains 35 per cent TCA. The BODY variant for the body contains 50 per cent, because the skin of the hands, elbows, knees, back or thighs is thicker. These are two different formulas, not the same preparation in two packagings, and the cosmetologist chooses the variant for the treatment area.
Why is BioRePeel sometimes combined with microneedling?
Microneedling increases the absorption of active ingredients, so the price list offers the preparation both on its own and combined with microneedling and with microneedle mesotherapy. Combining the two, however, means more intensive work and a more visible skin reaction, so the assessment at the consultation decides whether it makes sense.
Can the treatment be done in summer?
According to the preparation's materials, it can be used regardless of the season. Photoprotection after the treatment applies regardless of this, and for pigmentation indications it is decisive. The cosmetologist assesses the timing and season together with the condition of the skin.
Is the treatment safe for everyone?
No treatment is safe for everyone, and we do not use such a claim. The preparation is based on trichloroacetic acid, so the contraindications proper to acid peels apply, and qualification is carried out by the cosmetologist after assessing the skin and taking a history.
The content is for information. It does not replace a consultation, an examination or an individual assessment.